In this study two vaccines were prepared, Romanian sheep pox (RSP) and Ismailia lumpy skin disease (LSD) vaccines, they were evaluated and proved sterile and potent , and were used for vaccination of susceptible calves against lumpy skin disease for selection of the most appropriate one , depending on their  protectively effect .Twelve susceptible calves 6-8 months old were equally divided into two groups ,1st one was divided into two subgroups (each of 3 calves) ,the 1st one (G1) was vaccinated with RSP vaccine and the 2^nd one (G2) was vaccinated with LSD vaccine, vaccination was applied intra dermally with 0.5 ml contain 10³ log₁₀ TCID₅₀ the 2^nd group (6 calves) was divided into three equal non vaccinated control subgroups (Sg) (each of two calves), one left in contact with the 1^st vaccinated animal (G1) and the 2^nd Sg left in contact with the 2^nd  vaccinated calves (G2) while the 3^rd Sg calves were left as an isolated control Sg. The clinical changes and post vaccinal reactions recorded .The acquired humoral and cellular acquired immunity were evaluated by neutralization test and lymphocyte blastogenesis assay. The results proved that the second vaccinated subgroup (with LS vaccine) acquired a slight prominent immunity more than (SP vaccine) .generally both of Romanian SP and Ismailia LS vaccines can protect the cattle from infection with lumpy skin disease.