Thisstudy was conducted to evaluate the efficacy of Saltose (Biological product) and Salinomycin (Ionophore product) oncoccidiamixedinfection in Broiler. 90 broiler chicks were divided into three experimental groups, three replicates (10 birds each). Group A was fed on basal diet, group B fed on basal diet with  0.5 gm Salinomycin 12 % / kg feed and group C was fed on basal diet with 0.5gm Saltose /kg feed. At 20 days old, all groups were challenged with175000 mixed oocyst (Eimeria tenella, Eimeria maxima, and Eimeria acervulina) per ml oral gavage. Data collected before challenge and 7 days post challenge. The following behaviour patterns were measured;  feeding, drinking, leg and wing stretching, body scratching, preening and resting, also the final body weight, total feed intake, food conversion ratio and mortality rate were recorded. Moreover the estimation of Eimeria oocyst count and intestinal lesions were scored. Results obtained revealed that the behaviour patterns after challenge were significantly differ at P<0.05, as Group C showed higher feeding 17 ± 0.03%  followed by group B, 12 ± 0.01%. Also resting behaviour was higher in group A   61 ± 1.38 % followed by B 49.5 ± 3.4% and C, 34 ± 1.76%. Group C showed the highest average body weight 1810 ± 5.7 gm, following by group B 1710 ± 2.67 gm. The count of Eimeria oocyst in group A was 12×10³ /gm before challenge and 6×10⁵/gm after challenge, while in group B was 5×10²/gm before challenge and 7×10³/gm after challenge and in group C the count was 2.5×10²/gm before challenge and 6×10²/gm after challenge. From the obtained results it was concluded that biological control in Coccidiosis infection more efficient than ionophore control.