One Hundred chicks, one day old were divided into 10 groups. The first group was control negative and the second was control positive. The other eight groups treated either by Thymus vulgaris (1 or 2 ml/ 1 litter drinking water) or Zingeber officinale (5 or 10 ml/ 1 litter drinking water) from the first day old till the end of the experiment. Experimental infection was done orally to 4 groups only of the 8 groups at 10 days Growth parameters as body weights and feed conversion rates were the best in groups treated only with Thymus vulgaris or Zingeber officinale and higher doses were better than lower doses. Also, infected treated groups with higher doses of either Thymus vulgaris or Zingeber officinale extract were better than infected treated groups with low doses of either Thymus vulgaris or Zingeber officinale extract or infected only with the E.coli O78 strain. Blood leukogram pictures and advanced immunological (IL-1 beta, 6, 10, 12 and Tumor necrosis factor) profiles showed better results with higher doses of either Thymus vulgaris or Zingeber officinale extract in compare to lower doses of the same extract either infected with E.coli O78 or not infected. The experimentally infected groups showed better results in compare to control positive.