Current study investigated the effects of Nigella sativa (NS) and Curcumin on Aflatoxins (AFs) residues on some hepatic and renal functions in quails. A total 120 unsexed Japanese quails chicks one-week-old were equally divided for one month of experiment into 4 groups; G1, G2, G3 and G4. G1; was considered control group and was given AFs free diet, G2; was given 2.5 mg/kg diet AFs, G3; was given AFs 2.5 mg/kg diet and 1.5% NS and G4, was given 2.5 mg/kg diet AFs with Curcumin 400 mg/kg diet, respectively. Total cholesterol (TC), triacylglycerol (TG), high density lipoprotein- cholesterol (HDL-c), low density lipoprotein- cholesterol (LDL-c), creatinine, uric acid, and Aflatoxin residues were determined. Also the histopathological examinationon liver was performed. TC, TG and LDL-c were significantly (P≤0.5) increased in G2 than G1, while reduced in G3 and G4 than G2. However, HDL-c was significance (P≤0.05) decrease in G2 than G1. While, increased in G3 and G4 than G2. Creatinine and uric acid were significantly (P≤0.5) elevated in G2 than G1, while it was significantly (P≤0.5) decreased in G3 and G4 than G2. AFs residues in liver tissue was significantly (P≤0.05) elevated in G2 than G1 and significantly (P≤0.05) reduced in G3 and G4 than G2. This study indicated that Addition of NS and Curcumin to quails diets; improved via modulating lipid profile, creatinine, uric acid and reduction of AFs residues with respect to hepatic and renal function.