The present work was conducted for evaluation of the effects of iliac crest autograft (ICBG) and Hydroxyapatite / β tri- calcium phosphate (HA / β -TCP), on the healing process of an experimentally induced right femoral fractures with 0.5 cm × 0.5 cm partial bone defect at the fracture site in dogs fixed with standard dynamic compression plate (DCP) and self taping cortical screws. It was carried out on twenty seven apparently healthy male mongrel dogs divided into three equal groups, each of 9 dogs. Group I left as a control. Groups II and III were treated with ICBG and HA / β -TCP respectively. Clinical, radiographical and histological examinations were carried out for judgment of the healing process. This study came to the conclusion of; ICBG provides the most dense callus formation and the fastest possible healing. While, HA / β -TCP was an excellent substitute for ICGB that solve the problem of two operations on the same animal.