The present study was conducted on a total of 200 marine fishes (100 of Dicentrarchus labrax  and 100 of D.punctatus) collected from different private fish farms in Ismailia Governorate. There were no pathognomonic lesions in the naturally infested fishes except marbling appearance of gills infested by Isopoda. Skin lesions were found in opercular cavities of fishes infested by Isopoda. The main P.M lesions were hemorrhagic areas on EBS and emaciation. Some fishes showed Sea lice in the buccal cavity with ulcerative lesions in the area of attachment. The highest crustacean infestation rate was recorded in  Dicentrarchus labrax  (75%) followed by D.punctatus (42%). The isolated crustacean parasites from both fish species were copepods (Lernanthropus kroyeri, Caligus minimus and C.longipedis) and Isopods (Nerocila spp., Renocila spp. and Anilocra spp.).Total and Seasonal prevalence of crustacean parasites, histopathological picture and identification of copepod parasites using molecular biology (PCR) were also recorded.