Algae are an important source of secondary metabolites and several compounds that have a wide range of bioactivities. However, algae of the Red sea have not been adequately explored for their potential as a source of bioactive substances. In this study, Caulerpa sp., Chondria sp., Galaxaura sp., Turbinaria sp. and cystoseira sp., collected from Red sea, Egypt, were screened for their potential bioactivity. Algal extracts were prepared using Ethanol/Dichloromethane (1:1) solvent. It was found that the crude extract of Caulerpa sp. showed the highest antibacterial and anti-yeast activity among all tested extracts. It could be concluded that the Red Sea marine environment of Egypt has a potential to introduce pharmaceutically useful seaweeds as a great candidate for further investigations towards drug development, however further deep investigations are requested.