Background: Hepatocellular carcinoma (HCC) is the world's third leading cause of cancer death. The main risk factors for HCC are viral infection (particularly hepatitis C and B viruses) and alcohol. Herbal medicine-based therapy has become an effective therapeutic option for the treatment of many diseases, including liver cancer, in recent years. Materials and methods:  Four groups of adult male Swiss albino rats were divided: 1st negative control group; 2nd positive group:  HCC induction was done using tetra chloride carbon (CCL4) 1ml/kg was administered IP twice a week for three months to develop HCC; 3rd date palm extract:  rats treated with date extract (400 mg/kg b.wt/day) after induction of HCC; 4rd cisplatin group: rats treated with cisplatin (1.5 mg/kg b.wt/ i.p).  Blood, liver tissues samples were collected for some biochemical and histopathological studies. Once treatment was completed, animals were scarified with an injection of urethane (1g/kg body weight) at the end of the experiment. Results: Overexpression of liver enzymes was identified in Hcc cells when compared to treated groups. As these changes were accompanied by hepatic necrosis and inflammation.Conclusions: According to our findings, palm date extract may be useful as an anti-tumor therapeutic for HCC.