Background: Chronic renal disease is a public health concern worldwide. The epidemiology of this disease can help in the protection strategy. The detection of the polymorphism of the CKD candidate gene can assist in the early detection Chronic. And thus, early detection and treatment can often avoid or postpone the kidney disease. Objectives: Our research aimed to investigate how polymorphisms of the AXIN-1 gene and CKD incidence are associated with Egyptians. Methods: This study included 3 groups; control group, a pre-nephropathy group including (diabetes 2 and hypertension) subgroups, and a nephropathy group including (diabetic nephropathy, hypertensive nephropathy, and diabetic hypertensive nephropathy) subgroups. All the volunteers are subjected to complete clinical examination and routine laboratory analysis.  In this research, we performed genotyping for two SNPs (rs9921222 and rs1805105) throughout the Egyptian population (PCR-RFLP). Results: our results showed that in both (rs9921222 and rs1805105) SNPs, there was a significant difference in genotypes distribution (P<0.001) Conclusion: The AXIN-1 SNPs (rs9921222 and rs1805105) may be used as one of the Egyptian population's CKD susceptibility factors and larger studies can confirm our results.