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146586

Association between serum level of pentraxin-3 and interleukin-40 with HCC disease in Egypt

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Last updated: 24 Dec 2024

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Abstract

Background Hepatocellular carcinoma (HCC) is a global public health problem that lacks efficient methods for early diagnosis. The inflammation of the hepatocytes due to the cirrhosis caused by HCC can be reflected by the disturbance in the level of some proteins secreted by the inflammatory immune cells.  We aimed to study pentraxin-3 (PTX3) and interleukin-40 (IL-40) blood levels in patients with HCC  Material and method This study included 46 of  HCC patients and 24 of control with no history of malignancy. All the volunteers are subjected to complete clinical examination and routine laboratory analysis including CBC, coagulation profile tests, liver and kidney function tests. Serum levels of AFP, interleukin-40, and pentraxin-3 were measured by the ELISA technique Results Both PTX3 and IL-40 blood levels were significantly higher in HCC patients compared to healthy controls (P < 0.05). In addition both of them high AUC under ROC curve with significant value (AUC= 0.97, P <0.001; AUC=0.745, P= 0.016) for PTX3 and IL-40 respectively. Almost no studies have discussed the role of IL-40, which is new characterized cytokine, with HCC disease. Conclusions: This study suggested thatpatients with HCC showed increased presence of PTX3 and IL-40 serum level which may suggest a potential relationship of both of them with HCC. Although the role of IL-40 in HCC pathogenesis and development is still unclear but several studies have revealed that HCC progression is solely dependent on the extent of liver inflammation, hence, the balance between pro-inflammatory and anti-inflammatory cytokines is the key ingredient for controlling the disease progression.

DOI

10.21608/blj.2020.146586

Keywords

Pentraxin, 3 Interleukin, 40 HCC

Authors

First Name

Noha mohamed

Last Name

Said

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Affiliation

Biochemistry Division, Chemistry Department, Faculty of science, Zagazig University, Zagazig, Egypt

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First Name

Fathy

Last Name

Yassin

MiddleName

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Affiliation

Chemistry Department, Faculty of science, Zagazig University, Zagazig, Egypt

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Orcid

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First Name

Asmma M.

Last Name

Esh

MiddleName

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Affiliation

Clinical Pathology Department, Faculty of Medicine ,Zagazig university , Zagazig ,Egypt.

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Orcid

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First Name

Eman

Last Name

Saeed

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Affiliation

Biochemistry Division, Chemistry Department, Faculty of science, Zagazig University, Zagazig, Egypt

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Volume

16

Article Issue

1

Related Issue

21623

Issue Date

2020-12-01

Receive Date

2020-02-07

Publish Date

2020-12-01

Page Start

50

Page End

62

Print ISSN

1687-4773

Online ISSN

2974-4725

Article File

BLJ_Volume 16_Issue 1_Pages 50-62.pdf

PDF . 478.7kB

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https://blj.journals.ekb.eg/article_146586.html

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https://blj.journals.ekb.eg/service?article_code=146586

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Original Article

Type Code

988

Publication Type

Journal

Publication Title

Biochemistry Letters

Publication Link

https://blj.journals.ekb.eg/

MainTitle

Association between serum level of pentraxin-3 and interleukin-40 with HCC disease in Egypt

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Article

Created At

22 Jan 2023