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64445

SYNTHESIS AND STABILITY STUDY ON AN ASPIRIN DERIVATIVE WITH POTENTIAL SELECTIVE COX-2 INHIBITOR

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Last updated: 24 Dec 2024

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Abstract

       The synthesis of N– [5– Methyl– 2– (1, 3, 4 COX-2 selective inhibitor and the preliminary kinetic study for hydrolysis of this compound is studied in this paper. The compound was prepared from the corresponding aspirin and 2–amino–5–methyl–1,3,4–thiadiazole in the presence of N,N-dicyclohexylcarbodiimide (DCC) as coupling agent .        The preliminary kinetic study for hydrolysis of this compound and the effect of pH on the rate of hydrolysis in buffer solution citrate–phosphate–borate/HCl was studied. The structure was confirmed by infrared, nuclear magnetic resonance (H–NMR), and elemental microanalysis assay. The compound underwent slightly hydrolysis at low and high pH with a fairly stabile so, provide a chance for it to be absorbed intact with highly bioavailability, longer half life, and with lower G1 toxicity.

DOI

10.21608/blj.2008.64445

Authors

First Name

Al-Mikhlafi

Last Name

S. A.

MiddleName

-

Affiliation

Department of medicinal chemistry

Email

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City

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Orcid

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First Name

Othman

Last Name

A.M

MiddleName

-

Affiliation

Faculty of Pharmacy, Sana'a University

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Volume

4

Article Issue

1

Related Issue

9740

Issue Date

2008-12-01

Receive Date

2008-01-09

Publish Date

2008-12-01

Page Start

1

Page End

14

Print ISSN

1687-4773

Online ISSN

2974-4725

Article File

BLJ_Volume 4_Issue 1_Pages 1-14.pdf

PDF . 400.4kB

Link

https://blj.journals.ekb.eg/article_64445.html

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https://blj.journals.ekb.eg/service?article_code=64445

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Type

Original Article

Type Code

988

Publication Type

Journal

Publication Title

Biochemistry Letters

Publication Link

https://blj.journals.ekb.eg/

MainTitle

SYNTHESIS AND STABILITY STUDY ON AN ASPIRIN DERIVATIVE WITH POTENTIAL SELECTIVE COX-2 INHIBITOR

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Article

Created At

22 Jan 2023