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64420

THE RELATION BETWEEN THE RENIN-ANGIOTENSIN SYSTEM AND FIBRINOLYTIC SYSTEM

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Last updated: 04 Jan 2025

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Abstract

Background: Several lines of evidence point to an interrelation of the renin angiotensin system (RAS) with the endogenous fibrinolytic system. Aim & Methods: this study was planned to examine the effect of salt depletion as a method of activation of the endogenous RAS on plasma fibrinolytic balance in 10 healthy human subjects in the presence and absence of Angiotensin converting enzyme inhibitor- ACEi (captopril). Activation of the RAS during low salt intake was documented by a significant increase in serum aldosterone concentration. Results: the data suggest that activation of the RAS results in increased plasminogen activator inhibitors (PAI-I) antigen and that interruption of the RAS with the ACE inhibitor captopril significantly lowers PAI-I antigen without lowering tissue-type plasminogen activator (t-PA) antigen. Conclusion: this data provides an evidence of a direct functional link between the RAS and the fibrinolytic system in humans and these findings may help to elucidate possible mechanisms by which ACE inhibitionexerts vasculoprotective effects and reduces the risk of atherothrombotic events.

DOI

10.21608/blj.2010.64420

Authors

First Name

M. M.

Last Name

Al-Zendah

MiddleName

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Affiliation

Physiology &Biochemistry Departements - Faculty of Medicine Al-Fateh University for Medical Sciences

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Orcid

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First Name

A.

Last Name

Alfaqeh

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Affiliation

Physiology &Biochemistry Departements - Faculty of Medicine Al-Fateh University for Medical Sciences

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Volume

6

Article Issue

1

Related Issue

9732

Issue Date

2010-12-01

Receive Date

2010-01-11

Publish Date

2010-12-01

Page Start

18

Page End

31

Print ISSN

1687-4773

Online ISSN

2974-4725

Article File

BLJ_Volume 6_Issue 1_Pages 18-31.pdf

PDF . 196.1kB

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https://blj.journals.ekb.eg/article_64420.html

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https://blj.journals.ekb.eg/service?article_code=64420

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Original Article

Type Code

988

Publication Type

Journal

Publication Title

Biochemistry Letters

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https://blj.journals.ekb.eg/

MainTitle

THE RELATION BETWEEN THE RENIN-ANGIOTENSIN SYSTEM AND FIBRINOLYTIC SYSTEM

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Article

Created At

22 Jan 2023