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64245

EVALUATION OF MAGE-3 GENE m-RNA IN BLOOD AS POTENTIAL BIOCHEMICAL MARKER FOR HCC PATIENTS

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Last updated: 24 Dec 2024

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Abstract

Hepatocellular carcinoma (HCC) is the fifth most common neoplasm in the world, and the third most common cause of cancer-related death. Early diagnosis remains the key to effective therapy of HCC. Materials & Methods: In the present study Alpha-fetoprotien (AFP) by ELISA technique and MAGE-3 m-RNA in blood by RT-PCR were assayed in 140 individuals classified into 4 groups: control group (I) which comprised of 20 healthy individuals, group II which comprised of 20 hepatic patients without any complications; group III that comprised of 25 cirrhotic patients and group IV that comprised of 75 HCC patients.  Results: The results revealed that the positive rate of MAGE-3 transcripts among HCC patients was 36% (27 out of 75). The results of AFP showed a significant positive increase of serum AFP in group IV when compared with group I, II and III, also significant positive increase in group III when compared with group I and II.  Conclusions: MAGE-3 transcript in the blood can be used in diagnosis of HCC, to predict prognosis and monitoring of the response to the therapy, and AFP level directly correlated with progression of HCC.

DOI

10.21608/blj.2010.64245

Authors

First Name

Yousri M.

Last Name

Hussien

MiddleName

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Affiliation

Medical Biochemistry, Faculty of Medicine

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Orcid

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First Name

Faten Z.

Last Name

Mohammed

MiddleName

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Affiliation

Biochemistry Department, Faculty of Science

Email

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City

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Orcid

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First Name

Wael

Last Name

H. E

MiddleName

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Affiliation

Oncology Department, Faculty of Medicine3, Zagazig University, Zagazig, Egypt

Email

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Orcid

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First Name

Amal F.

Last Name

Ghareeb

MiddleName

-

Affiliation

Medical Biochemistry, Faculty of Medicine

Email

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City

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Orcid

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First Name

Al-shimaa M.

Last Name

Abas

MiddleName

-

Affiliation

Biochemistry Department, Faculty of Science

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Volume

7

Article Issue

1

Related Issue

9718

Issue Date

2011-12-01

Receive Date

2010-06-02

Publish Date

2010-12-01

Page Start

69

Page End

79

Print ISSN

1687-4773

Online ISSN

2974-4725

Article File

BLJ_Volume 7_Issue 1_Pages 69-79.pdf

PDF . 486.0kB

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https://blj.journals.ekb.eg/article_64245.html

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https://blj.journals.ekb.eg/service?article_code=64245

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4

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Original Article

Type Code

988

Publication Type

Journal

Publication Title

Biochemistry Letters

Publication Link

https://blj.journals.ekb.eg/

MainTitle

EVALUATION OF MAGE-3 GENE m-RNA IN BLOOD AS POTENTIAL BIOCHEMICAL MARKER FOR HCC PATIENTS

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Article

Created At

22 Jan 2023