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64240

IMMUNOTOXIC ACTION OF POSTORAL ADMINISTRATION OF CARBON TETRACHLORIDE IN MALE ALBINO RAT

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Last updated: 24 Dec 2024

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Abstract

            Carbon tetrachloride (CCl4) was administered (p.o.) every other day for one month to male Sprague Dawely rats. At the first day after the treatment period, leucocytes (WBCs), and lymphocytes (LYM) numbers, and serum IgM level were significantly higher than those of the control values. At day 15 after CCl­4 treatment period WBCs and LYM numbers were below the control levels, whereas, IgM was still above the control level, but lower than the value recorded at day one after CCl4 treatment period. The same dose level and treatment period of CCl4 induced significant increases in serum IL-4 and IL-6 levels that were lasted for 15 days post the administration period. Late administration (i.p.) of DMSO (0.5 ml/100 g b.wt.) at 30 minutes post CCl4 treatment period selectively prevented changes of WBCs and LYM.Tthese results indicate that the toxic effect of CCl4 under the present experimental conditions, could induce changes in both cellular and humoral immune response of rats and these changes could be selectively reversed with time and late administration of DMSO.

DOI

10.21608/blj.2010.64240

Authors

First Name

Nagi A.

Last Name

Ibrahim

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Affiliation

Zoology Department, Faculty of Science, Zagazig University

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First Name

Al Ahmady S

Last Name

Alzahaby

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Zagazig University

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First Name

Amr A.

Last Name

Shalaby

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Zagazig University

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Orcid

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First Name

Eman S.

Last Name

El-Bahaie

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-

Affiliation

Zoology Department, Faculty of Science, Zagazig University

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Volume

7

Article Issue

1

Related Issue

9718

Issue Date

2011-12-01

Receive Date

2010-02-05

Publish Date

2010-12-01

Page Start

23

Page End

43

Print ISSN

1687-4773

Online ISSN

2974-4725

Article File

BLJ_Volume 7_Issue 1_Pages 23-43.pdf

PDF . 307.2kB

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https://blj.journals.ekb.eg/article_64240.html

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https://blj.journals.ekb.eg/service?article_code=64240

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2

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Original Article

Type Code

988

Publication Type

Journal

Publication Title

Biochemistry Letters

Publication Link

https://blj.journals.ekb.eg/

MainTitle

IMMUNOTOXIC ACTION OF POSTORAL ADMINISTRATION OF CARBON TETRACHLORIDE IN MALE ALBINO RAT

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Article

Created At

22 Jan 2023