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63866

MODULATION OF INTERLEUKIN-6 AND IMMUNOGLOBULINS IgG AND IgM LEVELS AFTER MULTIPLE ORAL EXPOSURE TO LAMBDA-CYHALOTHRIN IN RATS

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Last updated: 24 Dec 2024

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Abstract

   Lambda-Cyhalothrin (LCT) is a synthetic pyrethroid insecticide used worldwide in agriculture , home best , and disease vectors control . The objective of this study was to investigate the propensity of LCT to induce changes in some humoral immune parameters in adult male Sprague Dawley rats . Animals were divided into four groups (5 rats each) . The 1st and 3rd groups were orally given 1/10LD50 (12.76 mg/kg body wt.) every other day for 8 weeks. The 2nd and 4th groups were orally given dist. water every other day for 8 weeks and served as controls for the 1st and 3rd groups respectively . Blood samples were collected from each animal under ether anesthesia through heart puncture and sera were separated , at the 1st and the 15th days post LCT administration form groups 1 and 2 and groups 3 and 4 respectively . Data obtained revealed that oral LCT induced a significant decrease in IL-6, and significant increases in serum IgG and IgM concentrations. Significant increases in serum AST activity , total protein and albumin concentrations and non-significant decrease in serum ALT activity . Recovery from these changes were dependent on the measured parameter. 

DOI

10.21608/blj.2013.63866

Authors

First Name

Nagi A.

Last Name

Ibrahim

MiddleName

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Affiliation

Zoology Department , Faculty of Sciences , Zagazig University

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Orcid

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First Name

Ahmed M.

Last Name

GabAllah

MiddleName

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Affiliation

Department of Clinical Pathology , Faculty of Medicine , , Zagazig University

Email

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Orcid

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First Name

Alsyed R.

Last Name

Farahat

MiddleName

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Affiliation

Zoology Department , Faculty of Sciences , Zagazig University

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Volume

9

Article Issue

1

Related Issue

9589

Issue Date

2013-12-01

Receive Date

2013-09-06

Publish Date

2013-12-01

Page Start

67

Page End

77

Print ISSN

1687-4773

Online ISSN

2974-4725

Article File

BLJ_Volume 9_Issue 1_Pages 67-77.pdf

PDF . 700.8kB

Link

https://blj.journals.ekb.eg/article_63866.html

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https://blj.journals.ekb.eg/service?article_code=63866

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7

Publication Type

Journal

Publication Title

Biochemistry Letters

Publication Link

https://blj.journals.ekb.eg/

MainTitle

MODULATION OF INTERLEUKIN-6 AND IMMUNOGLOBULINS IgG AND IgM LEVELS AFTER MULTIPLE ORAL EXPOSURE TO LAMBDA-CYHALOTHRIN IN RATS

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Article

Created At

22 Jan 2023