Background: Pregnancies are usually associated with increase tendency to thrombosis; many cases are associated with inherited or acquired risks.  Objective: The present study tested the mutations in Factor V Leiden (FVL) G1691A, prothrombin (PT) G20210A, methylene-tetrahydrofolate reductase (MTHFR) C677T genes, and their association with recurrent pregnancy losses in Egyptian women.  Results: The study included 150 subjects of a history of one or more recurrent pregnancy losses matched with 100 normal subjects with a history of normal delivery with no complications. FVL G1691A mutation was detected in (38%) of patients and in (5%) of control. PT G20210A mutation was detected in (6%) of patients with no detection in control. MTHFR C677T mutation was detected in (45.4%) of patients and in (4%) of control. Homozygous with mutant alleles for the three studied mutations were detected only among patients not control group.  Conclusion: There is a significant association between mutations of FVL, PT and MTHFR and recurrent pregnancy loss in Egyptian women.