The main objective of our study was to evaluate the correlation between CRP and homocysteine and the susceptibility to coronary artery disease , Our study also aimed to declar the association between fibrinogen gene 455G/A, Methylene tetra hydrofolate reductase (MTHFR) C677T and C-reactive protein(CRP) +1059G>C gene polymorphisms and susceptibility to coronary artery disease in the Egyptian population. Our study involved two groups:50 healthy control (age 38 – 62 years, Gp 1), and 50 patients (age 40 - 62, Gp 2) with coronary artery disease. Homocysteine, hs-CRP were detected, fibrinogen 455G/A, MTHFR C677T and CRP+1059G>C polymorphisms were detected based on the Polymerase chain reaction and restriction enzyme fragment length polymorphism (PCR-RFLP) method. Our study showed that homocysteine and C-reactive protein were associated with the incidence of coronary artery disease. Our study also found a significant increase in the fibrinogen 455G/A (AA genotype) and the MTHFR C677T gene (TT genotype) in patients compared to the control group. However, there was no significant difference in patients and control group in the + 1059 G>C polymorphism (CC genotype). We thus concluded that the 455G/A and MTHFR C677T polymorphisms were associated with coronary artery disease rather than +1059G>C that seem to be not associated with coronary artery disease.