protection against several diseases among humans. This study was carried out to evaluate the efficacy of hesperidin and tiger nut against the changes that may be related to the toxicity of acrylamide in female rats. 72 adult Sprague Dawley female rats were divided equally into six groups: control group (I); hesperidin (HES) treated group (II); tiger nut (TN) treated group (III); Acrylamide (ACR) treated group (IV); HES-ACR treated group (V); and TN-ACR treated group (VI). The treatments were daily administered for 4 months. There was a significant increase in the levels of serum carcino-embryonic antigen (CEA), malondialdehyde (MDA), protein carbonyls (CO), ALT, AST and LDH, while significant decreases of body weights and reduced glutathione (GSH) level and superoxide dismutase (SOD), catalase (Cat) and glutathione peroxidase (GSH-Px) activities of ACR treated group compared with the control. Also, many histopathological changes that observed in liver tissue in ACR group were regressed after HES or TN treatment. In conclusion, our results suggested that supplementation of a diet with hesperidin provided antioxidant defense more significant than tiger nut against the toxicity of ACR in the liver tissue.