H e p a t o c e l l u l a r c a r c i n o m a ( H C C ) is one of the most frequent malignant tumors. It is important to detect disease and recurrence at its earlier period. The aim of this study was to evaluate the influence of the C936T polymorphism of the VEGF And Alfa feto-Protein (AFP) on Hepatocellular carcinoma (HCC), Hepatitis C Virus (HCV) and control groups .Also, Estimation of serum AFP and correlation with other parameters. 25 patients with HCV, 25 patients with confirmed HCC and 25 healthy volunteers were subjected to abdominal ultrasonography, AFP and VEGF were assessed. The result has showed that Serum level of AFP was significantly higher in HCC group when compared with control group and There was a non significant increase in serum (AFP) level in the untreated HCV infected group compared to control group and also there was a non significant increase in serum (AFP) activity in the HCC group compared to untreated HCV infected group with a (P value = 0.203). the influence of the C936T