Background: Numerous studies have documented the association adiponectin (ADIPOQ) gene polymorphisms with obesity but the consequences are indecisive. The purpose of this work is to study the connection between adiponectin gene polymorphisms G276T and T45G with obesity and biochemical variants in Egyptian population. Material and methods: Genotyping of G276T single nucleotide polymorphisms of adiponectin gene was performed by Alleles Refractory Mutation Systems PCR(ARMS PCR) method, while Genotyping of T45G single nucleotide polymorphism of adiponectin gene was performed by RFLP PCR method. The analysis was done in 172 matched person; 89 obese patients, 43 overweight patients, and 40 normal healthy controls. Biochemical parameters were calculated through standard procedures. Results: For adiponectin polymorphism G276T, it was related to overweight under Co dominant and recessive models (P= 0.010, P= 0.036) respectively, also it was associated with obesity under recessive model (P= 0.048). Higher BMI was associated with heterozygous GT and homozygous GG carriers of G276T (P= 0.032) compared to TT carriers, For adiponectin gene polymorphism T45 G, it was associated with Obesity under Co dominant and dominance models (P= 0.046, P= 0.045) respectively. Heterozygous GT and homozygous GG carriers of T45G were related higher BMI (P= 0.029), triglyceride (P= 0.029), and VLDL (P= 0.026) compared to TT carriers at adiponectin polymorphism T45G. Conclusion: The study suggests that the ADIPOQ 276G>T and ADIPOQ 45T>G polymorphisms may be vital indicators of obesity and associated complications in several population.