Background: Nephrotoxicity was reported in the initial clinical trials of cisplatin chemotherapy. Aim of study: Our study was designed to evaluate the nephroprotective effect of Ginger extract promoted by cisplatin. Material & Methods: Animals were divided into7 groups as follow: Group1 (Control): Animals were injected intraperitoneal with 1ml single saline dose.Group2 (DMSO): Animals were administered orally with1 ml of 6.5% DMSO for 19 days .Group3 (cisplatin): Animals were injected intraperitoneal with cisplatin (10 mg/kg) as single dose to induce nephrotoxicity. Group 4 (Ginger only): Animals were administrated orally with 600 mg/Kg/day of ginger extract for 19 days. Group 5, 6 and7: Animals pretreated with oral dose of ginger extract (200, 400 and 600 mg /kg/day respectively) for two weeks before and 5 days after single IP cisplatin (10 mg/kg). Results: Administration cisplatin caused significant elevation in serum urea, creatinine concentration and kidney tissue levels of MDA and NO. Also caused significant increase in Caspase-3 levels, cisplatin significantly decreased level of Na. it decreased K, Mg and Ca level but statistically non-significant. Also it significantly decreased the antioxidant level of Catalase. Treatment with Ginger extract restored the levels of kidney concentration also oxidative stress markers in groups 5, 6 and 7 and also decrease Caspase-3 level. Also histopathological analysis confirmed that. Conclusion: ginger extract have a protective role in cisplatin induced nephrotoxicity.