Background: Nephrotic syndrome (NS) is one of the most commonly encountered glomerular diseases in children and a major contributor to the workload of pediatric nephrologists. Nephrotic syndrome is a chronic disease that is well known for its long term serious complications. among these complications albuminemia and dyslipidemia. Many studies has related albuminemia and dyslipidemia to other complications of Nephrotic syndrome as retinopathy and cardiovascular disease of nephrotic syndrome. Objectives: The main objective of this study was planned to elucidate the potential diagnostic role of transforming growth factor-beta (TGF-ß) as a novel biomarkers and its correlation with albuminemia and dyslipidemia in nephrotic syndrome among Egyptian children.  Methods: Serum level of TGF-ß was measured using ELISA, serum level of lipid profile and urinary proteins were estimated.  Results: Our study revealed that serum level of TGF-ß was higher in nephrotic cases than controls and its serum level was significantly negative correlated with serum albumin while it showed a significant positive correlation with urinary protein  and lipid indices levels in children with nephrotic syndrome (r= -0.88, P < 0.001) , (r= 0.85,P< 0.001) and (r=  , P < 0.001) respectively. Conclusions: our data confirmed that TGF-ß can serve as a potential diagnostic biomarker in nephrotic syndrome. Furthermore, it can assist in management of nephrotic syndrome pathogenesis due to its correlation with dyslipidemia and albuminemia which are the main clinical features of nephrotic syndrome.