Background: As Egypt's current policy is heading towards a comprehensive renaissance. Therefore, determining the risk factors of obesity, which represents the key factor for most chronic diseases and disability, is the right way to promote the health, social and economic aspects of Egyptian citizens. Wnts are secreted glycoproteins and comprise a large family of nineteen proteins in humans hinting to a daunting complexity of signaling regulation, function and biological output. Recent studies suggest that WNT10a may play a role in the negative regulation of adipocyte differentiation.  Objectives: The goal of our study is to investigate the association between Wnt10A gene polymorphisms and obesity risk in Egyptian population. In addition, we aimed to determine the participation of Wnt/β-catenin signaling pathway in adipogenesis by determining the serum β-catenin level. It is worth noting, that it is the first study to discuss Wnt10A gene polymorphisms and serum β-catenin level in Egyptian population. Methods: our study included 48 obese and 48 non-obese of Egyptian volunteers. All of them are unrelated persons without any chronic disease. All the subjects underwent the same investigations, including CBC, serum glucose level , lipid profile, serum β-catenin level, and  genotyping for Wnt10A gene polymorphisms (rs121908119- rs141074983) using RFLP-PCR method. Results: our results showed that (rs141074983) SNP is associated with obesity risk. There was high significant difference between obese and non-obese volunteers under codominant, dominant, heterozygote, and allelic models (P<0.05). The more interesting result was the association between obesity risk and minor allele carrier (T allele carrier; CT and TT) (OR=6.8 (1.3-47.6), p=0.007).  Regarding (rs121908119) SNP, there was a relatively difference in genotypes distribution between obese and non-obese volunteers but with no statistical power (p>0.05). Similarly, the decrease in serum β-catenin level in obese than non-obese volunteers lacked the required statistical confidence (p>0.05). Conclusion: The Wnt10a SNP (rs141074983) is strongly associated with increased risk for obesity in Egyptian population and larger studies can confirm our results.