Objective: The aim of this work was to investigate the relation of the glucocorticoid receptor gene polymorphism (BclI) with the rheumatoid arthritis (RA) activity. Method: This study included 20 volunteers controls and 70 patients with RA (35 in remission and 35 active). Serum α1 antitrypsin was measured for all subjects by radial immunodiffusion (RID) plates. Other markers of inflammation and disease activity were also detected. All subjects were genotyped for glucocorticoid receptor gene polymorphism using PCR-RFLP. Serum α1 antitrypsin was higher in active RA patients compared to inactive RA patients and controls. Results: Highly significant level of α1 antitrypsin was detected with variant genotypes. Significant association was found between the investigated BclI polymorphism and the parameters of the RA activity. Conclusions This study suggesting the relationship between glucocorticoid receptor gene polymorphism and the activity of RA.