Materials Requirements Planning (MRP) is currently one of the most popular manufacturing frameworks. Based on 13 manufacturing Pharmatheutical Company in Egypt in Great Cairo survey, the researcher found that the degree of the MRP positive implementation intense Pharmatheutical manufacturer's production operations performance, Ensures the availability of materials, components, products. Enhances production operations planning and controlling, customer delivery, maintains the optimal possible level of inventory, and plan manufacturing activities, delivery schedules, and purchasing activities. MRP creates synergy and attains better production and operations performance, and resulted in wide acceptance in the Egypt manufacturing Pharmatheutical field.