Aim: This study aims to evaluate the efficacy of platelet rich fibrin (PRF) in combination with perforated versus non-perforated collagen membrane in treatment of class II gingival recession.Subjects and Methods: fourteen patients having at least one tooth with Miller's Class II buccal/labial gingival recession defect after phase I therapy were classified into two groups, group 1 was treated with coronally advanced flap (CAF) combined with PRF membrane along with perforated collagen membrane and group 2 was treated with CAF combined with PRF membrane along with non-perforated collagen membrane. Clinical parameters were recorded at baseline, 1, 3 and 6 months postoperatively.Results: Both treatment groups showed significant root coverage, probing pocket depth (PPD) reduction, clinical attachment (CAL) gain and increase in width of keratinized gingiva (WKG) 6 months after surgery compared with baseline. However, there was a highly significant increase in WKG and CAL gain when collagen membrane was perforated.Conclusion: The perforated collagen membrane demonstrated clinical advantages beyond that achieved by the non-perforated one.