Aim: Post-operative pain is one of the main disadvantages of composite resin restorations, so the study will evaluate it after one day one week, and one month postoperatively. Subjects and methods: A total No. of 60 patients were selected randomly for the study, class II cavity preparation was performed with two different placement techniques; Bulk fill Tetric Evo-ceram and Nanohybrid composite Z250 XT. Two different adhesive systems were used Self Etch Clearfill SE and Adper Single bond. Post-operative pain is evaluated at one day, one week, and one month post-operative. One-way ANOVA analysis was used for statistics of the results. Results: From the results of the study there was no statistically significant difference between the tested groups, but it was noticed that all the groups gave higher results after one day postoperative, and all of them are decreasing after one week and more decreasing after one month post-operative. It was recorded that bulk fill has decreased post-operative pain and also self-etch groups have the lowest values than total-etch groups in both types of composite resin restorations. Conclusion: Post-operative pain and hypersensitivity in both bulk fill and incremental placement techniques is decreasing with time, and the adhesive system has no significant role in decreasing post-operative pain and hypersensitivity.