Aim: To compare the clinical and 3D volumetric socket bone preservation using Beta tri- calcium pohosphate plus collagen (B-TCP/Col) versus Platelet Rich Fibrin (PRF) assessed by 3D cone beam computed tomography. Subjects and Methods: 20 patients were treatment planned for extraction of mandibular and maxillary teeth, leaving 20 sockets for the study. Sockets were divided into 2 groups, each group consisting of 10 sockets. Sockets were grafted as follows: Group (I) sockets were grafted with B-TCP/col, Group (II) sockets were grafted with PRF. Cone beam computed tomography (CBCT) were done immediately and 3 months postoperatively, then collected data were statistically analyzed. Results: After 3 months, Bone height (mm) showed significant difference between the tested groups where Group A (B-TCP) produced the highest mean Bone height followed by Group B (PRF) . Bone width (mm) showed insignificant differences between the tested groups. Bone density showed insignificant differences between the tested groups. Conclusion: Beta tri calcium pohosphate plus collagen (B-TCP/Col) may be a adjunctive modality to accelerate bone formation in defective socket.