Acute kidney injury (AKI) develops in many of the patients admitted with history of envenomation and poisoning. Tubular injury initiated by toxins often results from a combination of acute renal vasoconstriction and direct cellular toxicity due to intracellular accumulation of the toxin. The aim of the present study was to evaluate (percentage, causes and outcome) acute kidney injuries among acutely poisoned patients. This cross-sectional study was carried out on all patients with acute kidney injury admitted to intermediate or intensive care unit (ICU) of Poison Control Center in Ain-Shams University Hospitals due to acute toxicity with drugs and toxins causing acute kidney injury. Participants were allocated retrospectively in the period from January 2018 to December 2018 and prospectively during the period of April 2019 to the end of September 2019. RIFLE staging in acutely intoxicated patients significantly impacted by serum creatinine, serum urea and eGFR. Outcome in acutely intoxicated patients significantly impacted by serum creatinine and eGFR. Patients should be pre-hydrated and GFR should be frequently monitored during the administration of a potentially nephrotoxic drug with careful assessment of hemodynamic and volume status using vital signs and physical examination.