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47724

Immunotoxicity of Some Pesticides in Egyptian Diabetic Children

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Last updated: 30 Jan 2023

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Abstract

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disorder that could be triggered by environmental pollutants in genetically susceptible individuals. The present study aimed to assess the immune response of different lymphocyte subpopulations in a group of diabetic children in relation to pesticides with highest Odds ratios (lindane and malathion).  One hundred and ten Egyptian children; their ages ranged from 1.2 to 10 years were studied. The control group comprised 35 healthy children, while the study group included 75 children (diagnosed as T1DM within the first month). Seven whole peripheral blood sample was collected from each child and was divided as follows: 5 ml blood was taken for toxicological analysis of pesticides residues using Gas Chromatography equipped with Ni63 Electron Capture Detector. The remaining 2 ml blood sample was collected in EDTA tubes and used immediately for testing immunological markers by using flowcytometry. The results revealed significant correlation as regards the expression of CD4 %, HLADR % and CD4/CD8 ratio in relation to lindane. While malathion (an organophosphate compound), shows a significant correlation with CD4 %, CD20 %, CD16 % and HLDAR % lymphocyte subsets in the diabetic group compared to healthy subjects. It is concluded that pesticides might play a role concerning the increased incidence of T1DM in children. 

DOI

10.21608/mjfmct.2012.47724

Keywords

Pesticides, Childhood Diabetes, Immunotoxicity

Authors

First Name

Rania

Last Name

Abdel-Rahman

MiddleName

Hamed

Affiliation

Forensic Medicine & Clinical Toxicology, Mansoura University, Egypt

Email

raniahamed73@gmail.com

City

Mansoura

Orcid

-

First Name

Doaa

Last Name

El Morsi

MiddleName

A.

Affiliation

Department of Forensic Medicine and Clinical Toxicology; Faculty of Medicine, Mansoura University, Egypt

Email

dr.doaa2014@outlook.com

City

Mansoura

Orcid

0000-0003-4129-8002

First Name

Sherin

Last Name

Abd El- Aziz

MiddleName

M

Affiliation

Department of Clinical Pathology; Faculty of Medicine, Mansoura University, Egypt.

Email

-

City

Mansoura

Orcid

-

First Name

Ashraf

Last Name

El-Sharkawy

MiddleName

A.

Affiliation

Mansoura University Children Hospital, Faculty of Medicine, Mansoura University, Egypt.

Email

-

City

Mansoura

Orcid

-

Volume

20

Article Issue

2

Related Issue

7191

Issue Date

2012-07-01

Receive Date

2012-02-11

Publish Date

2012-07-01

Page Start

1

Page End

15

Print ISSN

1110-5437

Online ISSN

2682-3217

Article File

MJFMCT_Volume 20_Issue 2_Pages 1-15.pdf

PDF . 40.7MB

Link

https://mjfmct.journals.ekb.eg/article_47724.html

Detail API

https://mjfmct.journals.ekb.eg/service?article_code=47724

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Original Article

Type Code

966

Publication Type

Journal

Publication Title

Mansoura Journal of Forensic Medicine and Clinical Toxicology

Publication Link

https://mjfmct.journals.ekb.eg/

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Article

Created At

22 Jan 2023