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47664

Can Rutin be Used as An Antidote for Acute Acetaminophen Induced Hepatic Toxicity? An Experimental Study

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Last updated: 30 Jan 2023

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Abstract

Acetaminophen (APAP) is the most commonly reported toxic ingestion in the world. Severe liver injury resulting from overdose of APAP remains a significant clinical problem. This study aimed to assess the use of rutin in the treatment of acute acetaminophen toxicity compared to N-acetyl cysteine (NAC) in mice. Sixty mice were divided into 6 groups; group (1) as a control group, group (2) was given toxic dose of acetaminophen 250 mg/kg once by intraperitoneal injection "i.p.", group (3) was given N-acetyl cysteine 204 mg/kg once i.p., group (4) was given 28 mg/kg rutin once orally, group (5) was given toxic dose of acetaminophen followed by N-acetyl cysteine after one hour once i.p. and group (6) was given toxic dose of acetaminophen followed after one hour by four oral doses of rutin at 12 h intervals. Animals were sacrificed 12h after the last treatment. Alanine transaminase (ALT) was measured and liver was removed and examined histopathologically. Results showed that acute acetaminophen hepatotoxicity was best treated by multiple doses of rutin rather than single dose of NAC. It is concluded that rutin can be used in treatment of acetaminophen induced acute hepatic toxicity. 

DOI

10.21608/mjfmct.2014.47664

Keywords

acetaminophen, Mice, Rutin, N-acetyl cysteine, Hepatotoxicity

Authors

First Name

Seham

Last Name

Gad El-Hak

MiddleName

-

Affiliation

Department of Forensic Medicine & Clinical Toxicology , Faculty of Medicine, Mansoura University, Egypt

Email

sehamgad@yahoo.com

City

Mansoura

Orcid

-

First Name

Amal

Last Name

El-Bakary

MiddleName

A

Affiliation

Forensic Med. & Clin. Toxicology, Mansoura Faculty of Medicine, Egypt

Email

aelbakary2015@gmail.com

City

Mansoura

Orcid

0000000262390521

First Name

Samera

Last Name

Shaaban

MiddleName

H

Affiliation

Forensic Medicine & Clinical Toxicology Department,Faculty of Medicine, Mansoura University

Email

drsameerashaaban@yahoo.com

City

Mansoura

Orcid

-

First Name

Wagdi

Last Name

Alkashef

MiddleName

F.

Affiliation

Department of Pathology, Faculty of Medicine, Mansoura University, Egypt

Email

-

City

Mansoura

Orcid

-

First Name

Nancy

Last Name

Abdulhaq

MiddleName

A.

Affiliation

Department of Forensic Medicine & Clinical Toxicology , Faculty of Medicine, Mansoura University, Egypt

Email

-

City

Mansoura

Orcid

-

Volume

22

Article Issue

1

Related Issue

7080

Issue Date

2014-01-01

Receive Date

2013-11-10

Publish Date

2014-01-01

Page Start

1

Page End

15

Print ISSN

1110-5437

Online ISSN

2682-3217

Article File

MJFMCT_Volume 22_Issue 1_Pages 1-15.pdf

PDF . 57.7MB

Link

https://mjfmct.journals.ekb.eg/article_47664.html

Detail API

https://mjfmct.journals.ekb.eg/service?article_code=47664

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Original Article

Type Code

966

Publication Type

Journal

Publication Title

Mansoura Journal of Forensic Medicine and Clinical Toxicology

Publication Link

https://mjfmct.journals.ekb.eg/

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Details

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Article

Created At

22 Jan 2023