The present study was designed to measure and compare various measurements of orbital apertures between male and female subjects using digital computed tomography. Also to assess the usefulness of orbital aperture measures as an aid in sex determination in sample of Egyptian population. The study included 92 subjects (44 males and 48 females) with age ranged from 18 to 65 years. The results showed that males exhibited greater mean values for all the measurements except for left orbital width that was slightly increased in females. There were significant differences (p<0.05) between males and females regarding right orbital height, right and left area and inter zygomatic distance. The accuracy of correct sex classification was achieved up to 74.7%. Discriminant analysis revealed that inter zygomatic distances showed significant discrimination (p= 0.028) between both sexes. Receiver Operating Characteristic (ROC) curve analysis for sex discrimination demonstrated that inter zygomatic distance at a cutoff of 96.7 had sensitivity 76.7%, specificity 65% and accuracy 71% (p<0.001). In conclusion, inter zygomatic distance was found to be the best reliable parameter and achieved the highest accuracy 71%. So, it was seen that inter zygomatic distance could be used for the sex determination from computed tomography.