Background: Transient Tachypnea of newborn is one of the most common respiratory problems in newborns. The cause of development of TTN is failure of transition from intrauterine to extra uterine life due to delay in absorption of lung fluids.
Objective: studying the effect of inhaled salbutamol on outcome of transient tachypnea of newborn.
Patients and Methods: This prospective study was attended at department of neonatology at El Azhar (Assuit) University & Sohag Teaching Hospital: Group I (50 cases): infants in this group receive salbutamol inhalation. Group II (50 cases): infants in this group don`t receive salbutamol inhalation.
Results: There were insignificant differences between two groups as regard needing of oxygen support and duration of oxygen as in salbutamol group lower number of cases needs oxygen support and cases that need it had lower duration versus no salbutamol group (P-Value < 0.001). There was a significant decrease in enteral feeding   initiation time (P-value < 0.001)  and hospital stay among cases received salbutamol versus no salbutamol (P-value <0.0001).
Conclusion: The current study indicated that administration of salbutamol in treatment of TTN patients causes improvement in the clinical parameters, as well as the initiation of oral feeding, a reduction in the need for oxygen therapy, a reduction in the need for advanced respiratory support and the duration of hospitalization