Background: Nanotechnology is one of the most rising up branch in modern science. A few ‎years ago, natural product therapies play an important role in health care. The major application of ‎nanotechnology in medicine was the development of nanoparticles as drug delivery system. The ‎main advantages of using nanoparticles are large surface area, controlled particle size, site specific ‎targeting, bioavailability, stability, biodegradable and controlled release of drug. Aim of the study: ‎The present study had tested the potential of curcumin – chitosan nanoparticles as a great chance to ‎apply the modern nanotechnology techniques in the prevention and treatment of liver fibrosis ‎induced by carbon tetrachloride (CCl4) in male albino mice. Materials and Methods: 30g mice were ‎divided into four groups; normal control, CCl4, prevention and treatment group. Mice were ‎intraperitoneal (ip) injected by CCl4 three times a week for 4 weeks with dose of 0.5 ml / kg body ‎weight to induce liver fibrosis injury. While, mice were orally administrated nano curcumin – ‎chitosan mixture (100 mg : 100 mg) / 1 kg body weight 5 times a week for 4 weeks as a technique of ‎prevention and treatment. Results: The results showed that nano curcumin – chitosan mixture ‎exerted a great potential as antifibrotic agent and it was showed clearly through regulation of ‎different parameters measured in this study such liver enzymes (ALT, AST & ALP), AFP, Caspase-‎‎3, oxidative stress biomarker (MDA), antioxidant activities (GSH & CAT) and histopathological ‎study.‎