Background: The most common malignancy of females of Egypt is breast cancer. It accounts for 32 per cent of women's cancer. Clarifying and assessing prognostic factors associated with breast cancer is essential as they are the corner stone to identify the high-risk groups that can benefit from adjuvant therapy and improve their prognosis for the disease. Study Objective: The aim of this study was to assess the role of serum omentin-1 levels in the Egyptian female population as prognostic markers for breast cancer. Patients and methods: Study subjects are 120 BC patients and 30 age and BMI matching health controls, serum omentin-1 levels have been investigated and correlated with the clinicopathological aspects of the BC patients Results : Our study revealed a significant difference in omentin-1 between healthy controls and BC patients, and a gradual increase in severity of the disease. Conclusion: our findings suggested that omentin-1 could be a diagnostic marker for early detection of cases and associated with the prognosis of breast cancer, supporting its role as biomarkers of the prognosis.