Background: Breast cancer is the most prevalent cancer and one of the most common mortality causes among females worldwide. Accordingly, it is a main concern of scientists and doctors. Evolving serum tumor markers helping to early diagnosis of the breast cancer and estimating important prognostic factors is then mandatory. Among them are the cancer antigen 15-3 (CA15-3) as well as the carcinoembryonic antigen (CEA). Some researchers concluded their prognostic importance while others not. Aim of the study: This research was aimed at assessing the prognostic function of CA 15-3 and CEA in the Egyptian females. Patients and methods: Research participants are 120 BC patients and 30-year-old and BMI corresponding safety checks; the rates of CEA serum and CA 15-3 were studied and associated with the clinicopathological features of BC patients. Results: Our study showed that both markers differed significantly between healthy controls and patients with BC, and gradually increased with severity of the disease. Conclusion: our findings suggest that the levels of serum CA 15-3 and CEA and are intimately related to the prognosis of breast cancer, as they revealed a gradual increase with the severity of the disease, supporting their role as biomarkers of prognosis.