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97441

Clinicopathological and Immunohistochemical Study of High Grade Serous Ovarian Carcinoma

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

Oncology and nuclear medicine.
Pathology.

Abstract

Background: High grade serous ovarian carcinoma has a heterogenous morphology and marked genomic instability with aggressive behavior and poor overall prognosis. A molecular classification of HGSOC demonstrated 4 subtypes; C1, C2, C4 & C5 as a trial to correlate this molecular classification with patient prognosis. A correlation between these molecular subtypes, clinical data, histopathological criteria and immunohistochemical features needed to be established aiming at individualization of the treatment of each patient to achieve the best outcome.
Aim: Investigating for a correlation between the histopathological classification of high grade serous ovarian carcinoma (HGSOC), clinicopathological parameters, and immunohistochemistry.
Methods: Eighty five cases of high grade serous ovarian carcinoma were revised for their clinical data regarding their age, pathological staging, CA 125 levels, ascites, and chemotherapy regimen taken. The cases classified into four groups. Paraffin-embedded HGSOC specimens were re-cut at 5 microns thickness sections and stained with haematoxylin and eosin stain and examined for the different histopathological criteria. The tissue sections were also stained immunohistochemically with antibodies against Ki67, CD8, E cadherin, Vimentin, ER & PR.
Results: HGSOC could be classified into 4 groups (mesenchymal, immunoreactive, Proliferative & differentiated type either with SET features or papillary features). Ki 67 & CD8 had a strong significant correlation with the proliferative subtype & immunoreative subtype respectively (P< 0.001). Low PR expression was also correlated with advanced stage disease in cases underwent 1ry debulking surgery (P=0.03). in cases received neoadjuvant treatment, differentiated subtype with SET features showed a statistically significant correlation with high CD8 expression.

DOI

10.21608/muj.2020.29356.1011

Keywords

HGSOC, Histopathological classification of HGSOC, IHC of HGSOC

Authors

First Name

Marwa

Last Name

Khashaba

MiddleName

Hosny

Affiliation

pathology department, faculty of medicine, Portsaid university, Portsaid, Egypt

Email

marwahosny86@hotmail.com

City

portsaid

Orcid

-

First Name

Reham

Last Name

Nagib

MiddleName

Mohamed

Affiliation

pathology depatrment, faculty of medicine mansoura university

Email

nagibreham@yahoo.com

City

Mansoura

Orcid

-

First Name

azza

Last Name

abdelaziz

MiddleName

-

Affiliation

pathology department faculty of medicine mansoura university

Email

azza3a@yahoo.com

City

-

Orcid

-

First Name

Ghada

Last Name

Eladawy

MiddleName

Ezzat

Affiliation

department of nuclear medicine faculty of medicine mansoura university

Email

ghadaeladawy@hotmail.com

City

-

Orcid

-

First Name

Mohammed

Last Name

Mohamed

MiddleName

Fawzy

Affiliation

pathology department faculty of medicine mansoura university

Email

mohamedfawzy@hotmail.com

City

mansoura

Orcid

-

Volume

2

Article Issue

2

Related Issue

14013

Issue Date

2020-07-01

Receive Date

2020-05-03

Publish Date

2020-07-01

Page Start

15

Page End

37

Online ISSN

2682-2741

Link

https://muj.journals.ekb.eg/article_97441.html

Detail API

https://muj.journals.ekb.eg/service?article_code=97441

Order

12

Type

Original Article

Type Code

946

Publication Type

Journal

Publication Title

Medicine Updates

Publication Link

https://muj.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023