Background: Resistant infective corneal ulcer is an ocular emergency which needs an early and aggressive management to avoid its serious complications. Despite the availability of a wide range of newer antimicrobials, new diagnostic techniques and recent treatment modalities, infective keratitis continues to pose a diagnostic and therapeutic challenge. Objective: To evaluate the effectiveness and safety of the use of the argon laser in treatment of cases with resistant infective corneal ulcers. Patients and methods: Thirty patients with different forms of resistant infected corneal ulcers included in this study attended the cornea unit in the Ophthalmology Department at Al-Azhar University Hospitals. The cases were treated with argon laser, during the period from May 2019 to August 2020. We followed up the cases to detect the response to the argon laser until complete healing was achieved. Each case was followed up for 3 months to detect any relapse or recurrence. Results: We found that 86.6 % of cases healed without relapse (56.6 % of cases healed after about 2 weeks from laser therapy, 13.3 % healed after about 3 weeks, and 16.6 % healed after about 4 weeks), while 13.3 % of cases healed with relapse. Amniotic membrane grafting was needed in 13.3 % of cases. Conclusion: Argon laser, in most of cases, led to complete healing with small corneal opacity.