Background: Tuberculosis, is an infectious mycobacterial disease either by inhalation, or direct contact with Tuberculosis bacilli. With 10.4 million persons, tuberculosis (TB) is a global public health concern. Significant factor in the decline of Tuberculosis is early diagnosis of the disease, efficient chemotherapy and prevention of disease transmission. Objective: To study the pattern of tuberculosis in Kafer El-Sheikh Chest Hospital. Patients and methods: This retrospectively study conducted on the result of patient diagnosed as a tuberculosis cases at Kafer El-Sheikh Chest Hospital during the period from January 2008 to January 2018. One thousand and two hundred and sixty patients were included in this study, and diagnosed according to National Egyptian TB control Programme (NTP) and guidelines of the Egyptian Ministry of Health. The total number of TB cases was 1260: 1034 cases of them (82%) were pulmonary, while 226 cases (18%) were extra pulmonary. Results: the total numbers of TB cases were (1260), 1034 cases of them (82%) were pulmonary, while 226 cases (18%) were extra pulmonary. The total number recorded of T.B cases was 1260, the largest number of them was recorded in 2013(166) cases (13.2%), and the least number was recorded in 2009 (68) cases (5.4 %). In the current study 745 out of 1260 were males (59%),while 515 were females (41%). The mean age of TB cases was 39 years. There was no statistically significant difference as regards age between patients with pulmonary and patients with extra pulmonary TB. The total number of mortality was 41 cases, where the majority of them were recorded in 2010 (7.6%), and in 2013 was 0.6%. Conclusion: TB affects the most productive age groups, and this necessitated more attention in TB control programs targeting those age groups. TB incidence was higher in males especially in pulmonary TB.