Background: Patients with inflammatory bowel disease (IBD) are at an increased risk for venous thromboembolism (VTE). VTE events carry significant morbidity and mortality, and have been associated with worse outcomes in patients with IBD. Studies have suggested that the hypercoagulable nature of the disease stems from a complex interplay of systems that include the coagulation cascade, endothelium, immune system, and platelets. Additionally, clinical factors that increase the likelihood of a VTE event among IBD patients include pregnancy, active disease, more extensive disease, hospitalization, and IBD-related surgeries. Objective: To assess the platelet-leukocyte aggregation in patients with IBD and its relation to disease activity. Patients and Methods: This was a prospective cohort study conducted on 40 IBD Patients and 20 control cases who were admitted to Al-Hussein University Hospital, and some selected from outpatient clinic, during the period from 15^th of April, 2020 to 31^st of March, 2021. All participants underwent to clinical examination, laboratory findings, colonoscopy, histopathology and flowcytometric findings were recorded from patients. Results: There was a statistical significant difference (p-value < 0.001) between studied groups as regard hemoglobin level, white blood cells and platelets count. Statistical significant difference (p-value < 0.05) was found between studied groups as regard erythrocytic sedimentation rate and statistical significant difference (p-value < 0.001) between studied groups as regard C reactive protein and Fecal calprotectin. Also, there was a statistical significant difference (p-value < 0.001) between studied groups as regard ulcer, ileitis and edematous mucosa. Statistical significant difference (p-value < 0.001) was found between studied groups as regard platelet leukocyte aggregates. Conclusion: In patients with active inflammatory bowel disease (IBD), there was a significant high level of platelet leukocyte aggregates (PLAs), which might be explanation phenomena of increased risk for thrombosis.