Background: Infertility is estimated to affect between 8-12% of reproductive aged couples worldwide, and is caused by a combination of factors in both parents to prevent conception from occurring. The tubal and uterine factors of infertility are responsible for the main percentage of female infertility, and hence evaluation of tubal patency and intact uterus represent a key step and basic investigation in the assessment of infertile women. Objective: To observe the role of saline infusion sonohysetrography (SIS) to find out endometrial pathology and tubal patency in infertility woman. Patients and Methods: The present study was carried out at Radio-Diagnosis Department of Farafra Hospital during the period between January 2021 and March 2021 on 30 patients in reproductive age who presented with inability to conceive, 16 cases (53.3%) were of primary infertility, while 14 cases (46.7%) were of secondary infertility. All patients underwent the transvaginal scanning to evaluate any potential pathological condition without injection of saline. All patients underwent transvaginal scanning with injection of saline transcervically into uterine cavity. Results: There were 16 (53.3%) as a primary group, and 14 (46.7%) as a secondary group. The mean age 27.23 and SD 4.20 years, and 8(26.7%) with age < 25 and 22(73.3%) with age > 25. There was a statistically significant difference between the two groups regarding age, and non-significant regarding endometrial hyperplasia, submucus fibroid, endometrial polyp, ovarian cyst/mass, hydrpsalphnix, synechiea, congenital, bilateral patencytube, bilateral block tube and unlateral block tube. Conclusion: Saline infusion sonohysetrography can be used as a simple, noninvasive, cost-effective and useful tool in the work up of infertility patient, with better compliance and better results, with no radiation exposure to patients in evaluation of female infertility.