Background: Substance abuse is a growing problem in the world. In Egypt, as in many developing countries, substance abuse is a growing problem that worries both people and government. Objective: To investigate whether there are any psychiatric manifestations in patient using new synthetic psychoactive substance (strocks) or not. Patients and Methods: Cross-sectional observational study conducted in Psychiatry Hospital, The Armed Forces Medical Complex in Maadi and National Center for Addiction Treatment in Ismailia starting from September 2019 till December 2020.one hundred and seventy five patients were examined and confirmed to be strocks abusers with urine toxicology test (-ve) and confirmed by K2 one step synthetic cannabinoids test Device. Patients were Interviewed, Full general psychiatric history taking and mental state examinations regarding DSM-V criteria. Results: Mean age was(22.9 ± 3.2) and 80% of patients were males. Regarding psychiatric disorder among 175 strocks abusers, 15 patients with no psychiatric disorders, maladjustment disorder was in 30 patients, mixed anxiety and depression was 70 patients, schizophrenia was 35 patients, mixed personality trait was 5 patients, while border personality disorder in 20 patients Conclusion: Most of strocks abusers have psychiatric disorders like maladjustment, mixed anxity & depression, schizophrenia, mixed personality trait and border personality disorder.