Background: Diabetic nephropathy is a clinical syndrome characterized by persistent microalbuminuria in concomitance with diabetes mellitus. There is an urgent prerequisite for sensitive and/or more specific diagnostic and prognostic biomarkers for diabetic nephropathy   serum ferritin levels reflecting the body iron stores, is known to be elevated in type 2 diabetes mellitus. However, its association with diabetic complications, including diabetic nephropathy (DN) and overall glycemic control, needs to be validated. Objective: To identify and evaluate any association between elevated serum ferritin, glycemic control, microalbuminuria and other markers of diabetic nephropathy in patients with type 2 diabetes. Patients and methods: The present study involved 80 patients who were receiving chronic care for type 2 diabetes at the outpatient clinics of Al-Obor Insurance Hospital during the period from January 2020 to March 2021. The selected subjects were divided into three groups: Group I included 20 healthy normal non-diabetic control subjects, age and sex matched. Group II included 40 patients who had type 2 diabetes mellitus without nephropathy, and Group III included 40 subjects who had diabetic nephropathy. Results: The results of the present study revealed that both fasting and 2hPP blood glucose level was higher in diabetic patients with nephropathy  compared to that detected in diabetic patients without nephropathy - and healthy controls and so for glycated hemoglobin (HbA1c) with mean value for diabetic patients with nephropathy, diabetic patients without nephropathy and healthy controls.      The results showed a progressively increase in the mean level of ferritin in diabetic groups. ANOVA test showed a statistically significant difference in the mean level of ferritin among different studied groups with F=24.971 and P<0.001. Post hoc test serum ferritin concentration increased significantly from control to diabetic without nephropathy groups, and from diabetic without nephropathy groups to diabetic nephropathy group (all P<0.05). There was a significant negative correlation between ferritin and eGFR. Pearson's correlation test revealed significant positive correlation between ferritin and each SGOT, SGPT, cholesterol, triglycerides, and LDL-c levels. However, there was no significant correlation between ferritin and HDL-c. Conclusion: Patients with diabetes with higher serum ferritin were more likely to be associated with diabetic nephropathy. So, elevated serum ferritin level may be a useful marker for occurrence of nephropathy in diabetic patients.