Background: Polycystic ovary syndrome is a heterogeneous clinical syndrome, which has been defined as the association of hyperandrogenism with chronic anovulation in women without specific adrenal and pituitary gland disease. Objective: To compare the effect of laparoscopic ovarian drilling and ultrasonographic transvaginal ovarian drilling on patient with polycystic ovaries. Patient and Methods: Forty women with ultrasonographic as well as clinic and /or biochemical findings consistent with PCOs will be recruited into the study from the outpatient infertility clinic at Syed Galal hospital between June 2015 and June 2016. All patients in the study are seeking for treatment of infertility. These patients are randomly divided into two groups; one group has traditional laparoscopic ovarian drilling while the other group has transvaginal ultrasonographic ovarian drilling. Results: that there was a significant increase in FSH in both groups after treatment, but the improvement was higher in GI. Conclusion: In this study we found that there was a restoration to normal cycle in both groups with marked improvement in GI than GII in all parameters (ovulation rate and pregnancy rate).