Background: Bariatric surgery has been shown in multiple studies to produce substantial durable weight loss and improve or cure many of the symptoms of metabolic syndrome including type II diabetes, hypertension, sleep apnea and hyperlipidemia. Objective: To review the difference between laparoscopic single anastomosis duodeno-ileal bypass with sleeve gastrectomy versus mini-gastric-bypass regarding the efficacy for control of type 2 diabetes mellitus in obese patients. Patients and Methods: This was a prospective study which was done in between Dec 2018 - Dec 2020 at Al-Azhar University Hospitals, Cairo, Egypt. The study included 50 obese patients with type 2 Diabetes. The patients were divided to two groups. Group one had laparoscopic single anastomosis duodeno-ileal bypass with sleeve gastrectomy and group two had mini-gastric-bypass and follow up was carried for one year. Operations were operated by the same surgical team at Al-Azhar University Hospitals. Results: The mean BMI loss after one year from SADIS surgery was 21.6 kg/m2 ± 2.0034 kg/m2 versus 20.6 kg/m2±1.0239 kg/m2 in MGB procedure. Complete resolution of diabetes occurred in 88 % in SADIS versus 84 % in MGB operation. Regarding hypertension, resolution of hypertension was 76.7% in SADIS versus 66.5 % in MGB. Regarding Hyperlipidemia, resolution in 92%, improvement in 8% in SADIS operation versus 88% resolution, 12% improvement, 8 % minimal effect in MGB operation. Conclusion: The effect of laparoscopic single anastomosis duodeno-ileal bypass with sleeve gastrectomy and mini-gastric-bypass on the glucose metabolism and weight reduction has a profound impact in treating T2DM. It was a safe solution for carefully selected patients with metabolic syndrome; which decrease the risk of cardiovascular and metabolic diseases.