Background: Sleep disturbances are common symptoms of multiple sclerosis (MS). Patients with multiple sclerosis (MS) often have unrecognized sleep disorders at higher frequency than the general population such as insomnia, sleep disordered breathing, circadian rhythm disorder, restless legs syndrome (RLS), narcolepsy, and rapid eye movement (REM) sleep behavior disorder. Objective: To assess different types of sleep disorders in patients with multiple sclerosis in order to ensure early diagnosis and adequate treatment of such patients. Patients and Methods: All patients with clinically confirmed MS were included in the current study from the MS unit of Neurology Department, Al-Azhar University Hospitals, during the period from October, 2018 to October, 2020. Those patients were furtherly assorted based on McDonald's Criteria, 2017. Results: In the present study, 44 patients with confirmed diagnosis of multiple sclerosis were enrolled. Thirty one (70.45%) of the MS patients were classified as poor sleepers. They had decreased sleep efficiency, increased sleep latency, increased periodic limb movement (PLM) index, respiratory disturbance index (RDI), decreased REM sleep percentages, and decreased depth of sleep. Conclusion: Sleep disorders are frequent in MS patients, prompt recognition and treatment, which is tailored toward the individual's clinical issues and potential underlying causes, are necessary to optimize functional status and quality-of-life.