Background: Obesity and overweight raises adverse changes in lipid profiles as complications of obesity, while decreasing or increasing the related obesity indices such as BMI and waist circumference might affect the parameters of lipid. Objectives: To assess lipid profile in school-age obese children. Patients and methods: This case-control study was conducted on 80 Egyptian children divided into 4 equal groups according to anthropometric indexes: Overweight group, central obesity without general obesity group, central obesity with general obesity group and control group. All children were subjected to history taking, complete clinical examination, local systemic examination, complete blood count and fasting lipid profile. Results: There was a statistically significant difference between the studied groups regarding skipping breakfast, access to soft drink at home, consumption of sweetened drink per week and frequency of fruit consumption. Higher percentage of control (Normal weight) group reported significantly less frequency of skipping breakfast (<3times/week),  no access to soft drink at home, fewer consumption of sweetened drink per week (<3 times/week), and higher frequency of fruit consumption (≥3times/week). There was a statistically significant difference between the general central obesity and overweight groups regarding serum triglycerides, total cholesterol, LDL, VLDL and HDL cholesterol. There was a statistically significant difference between the general central obesity and control groups regarding serum triglycerides, total cholesterol, LDL, VLDL and HDL cholesterol. A statistically significant difference was between the central obesity and overweight groups regarding serum triglycerides, total cholesterol, LDL, VLDL and HDL cholesterol. Significant difference was found between the central obesity and control groups regarding serum triglycerides, total cholesterol, LDL, VLDL and HDL cholesterol. Conclusion: Detection of abnormalities in lipid profile such as high TG and low HDL-C levels in overweight and obese children can help in preventing the child from progression to metabolic syndrome.