Background: There are behavioral/emotional and physical/psychological effects caused by acne. Q-switched Nd: YAG laser with topical carbon suspension could provide satisfactory clinical results for the treatment of inflammatory acne. Objective: To evaluate the efficacy of Carbon Assisted Q-Switched Nd:YAG Laser Treatment for inflammatory acne. Place of study: Al-Hussein University Hospital, Cairo, Egypt. Patients and methods: This was a prospective split-face simple randomized clinical trial  carried out during the period from October 2019 to March 2021 including 20 patients of all ages and both sexes with clinical diagnosis of inflammatory acne. Results: The counts of all types of active acne lesions in Carbon side were steadily reduced from the first session. Eight weeks after completing the sixth session, the improvement rate of the inflammatory lesions was 32% on average 40% of patients had a poor response, 20% had moderate response, and 40% had a good response. Nobody reported excellent response. The effective rate (rate of success) was 40%.The other side showed low response rate that was 8.6% on average where 70% had a poor response. Only 30% (6 patients) had a moderate response, and nobody reported excellent response. The effective rate (rate of success) was 0%. There was a statistically significant difference between both sides regarding improvement, acne count and patient satisfaction, and no severe side effects were reported. Conclusion: Carbon assisted Q switched Nd-YAG Laser has a safe and fair effect in treating active inflammatory acne, while Q switched Nd-YAG Laser alone has aweak effect in treating active inflammatory acne indicating that Carbon lotion augmented the effect of the Laser.