Background: Narrow band imaging (NBI) is a new technique that uses optical filters for imaging of mucosal morphology. Thus, it can identify colonic polyp/mass through pit pattern and vascular pattern. Objective: To evaluate the efficacy of NBI in comparison with chromo endoscopy and conventional colonoscopy for detection of colorectal lesions. Patients and Methods: This study was carried out at Hepatology, Gastroenterology and Infectious diseases Department, Al-Hussein University Hospital. The study population included 200 patients from April 2019 to November 2020.By colonoscopy, 37 patients were excluded that had internal hemorrhoids, colonic diverticula, colonic ulcers or no abnormal colonoscopy finding. The rest 163 patients had colonic polyp/masses were divided into two groups. Group I included 102 patients who had colonic polyps, and Group II included 61 patients with colonic masses. The two groups underwent NBI (using NICE classification), chromo endoscopy (using Kudo classification), and biopsies were taken for histopathology. Results: There was a statistically significant relation between histopathological characters of the polyps/masses and their characters by NBI /chromo endoscopy (P < 0.001). NBI /chromo endoscopy can detect adenocarcinoma with 100% sensitivity and 94.7% specificity. Sensitivity and specificity for hyperplastic polyp was 93.5% and 91.5% respectively. Adenoma was 90.9% and 89.4% respectively. Sensitivity and specificity for malignant masses was 100% and 60%respectively. Conclusion: NBI can detect either colorectal polyp or mass, and predict its histology more rapid and simple than chromo endoscopy which needed stains and time consuming. Thus, can reduce the cost of the health system and the risk of polypectomy.