Background: Multi-detector computed tomography (MDCT) helps in evaluation of small bowel diseases such as small bowel wall lesions especially differentiation of benign and malignant lesions, Small bowel obstruction (SBO), Mesenteric arterial thrombosis, mesenteric venous thrombosis, or no occlusive mesenteric ischemia, chronic mesenteric ischemia the diagnosis of them is made by MDCT. Objective: To assess the efficacy of MDCT in diagnosis and evaluation of various small bowel diseases such as Meckel's diverticulum, small bowel obstruction, inflammatory bowel diseases, and bowel Ischemia. Patients and methods: Study was done at the Department of Radiology at Belbis General Hospital through a period from February 2020 to November 2020.It included 30 patients: 22 were malesand8 were females, with acute and recurrent abdominal pain, vomiting and distention. Their ages ranged between 35- 81 years with a mean age of 59.35 years old. Results: Our results showed sixteen patients had vascular disease. Four patients had intestinal obstruction, six patients had inflammatory disease, three patients had neoplastic disease, and one patient showed mesenteric panniculitis. Conclusion: MDCT allowed detection of mural enhancement after intravenous contrast.Combination with positive oral contrast was better used in neoplastic cases to outline the mass and differentiate it from the surrounding is Odense structures. It is also better used in cases with incomplete intestinal obstruction to confirm passage of contrast distal to the site of obstruction.